Off-label ophthalmic compounded therapy to inhibit corneal scarring and restore transparency.
Losartan potassium is an oral antihypertensive drug. However, recent ophthalmic research shows that topical application has a powerful anti-fibrotic effect. Since it is not commercially manufactured as an eye drop, topical losartan must be custom-made as a compounded sterile medication (galenico) by a specialized pharmacist upon a specific medical prescription.
Blocks the Transforming Growth Factor Beta (TGF-β) receptor, which drives tissue fibrosis.
Prevents keratocytes from transforming into opaque myofibroblasts, keeping the cornea clear.
Promotes orderly healing after ocular trauma or surgery, reducing haze.
Scenarios where specialists evaluate topical losartan (off-label use).
Losartan is not a standard drop for common dry eye, but a targeted therapy for structural corneal management.
As a master preparation, the ophthalmologist writes a non-repeatable prescription (off-label use). The compounding pharmacist uses pure raw material to create the drops in a sterile cleanroom. This allows for a customized dosage (typically 0.8 mg/ml, or 0.08%), preservative-free if necessary. The eye drops usually have a short shelf life (30-90 days) and should be stored below 25°C as indicated on the label.
Healing corneal ulcers is complex. To prevent scarring (Losartan's action), it is often necessary to first support epithelial closure. Specialists may prescribe high-impact regenerative therapies like Autologous Serum Eye Drops or compounded Topical Insulin.
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